The primary endpoint was time to onset of an NMOSD attack, as determined by the adjudication committee. Participants, investigators, and all clinical staff were masked to the treatments, and inebilizumab and placebo were indistinguishable in appearance. Inebilizumab or placebo was administered on days 1 and 15. Participants were randomly allocated (3:1) to 300 mg intravenous inebilizumab or placebo with a central interactive voice response system or interactive web response system and permuted block randomisation. Eligible participants were adults (≥18 years old) with a diagnosis of NMOSD, an Expanded Disability Status Scale score of 8♰ or less, and a history of at least one attack requiring rescue therapy in the year before screening or at least two attacks requiring rescue therapy in the 2 years before screening. We did a multicentre, double-blind, randomised placebo-controlled phase 2/3 study at 99 outpatient specialty clinics or hospitals in 25 countries. We aimed to assess the efficacy and safety of inebilizumab, an anti-CD19, B cell-depleting antibody, in reducing the risk of attacks and disability in NMOSD. No approved therapies exist for neuromyelitis optica spectrum disorder (NMOSD), a rare, relapsing, autoimmune, inflammatory disease of the CNS that causes blindness and paralysis. 12 Icahn School of Medicine at Mount Sinai, New York, NY, USA.11 Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.10 UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.9 Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-inflammation, Lyon University Hospital, Lyon, France.
8 Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.7 Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine, Berlin, Germany Charité-Universitätsmedizin Berlin, Berlin, Germany.6 Department of Multiple Sclerosis Therapeutics, Fukushima Medical University, Fukushima, Japan Multiple Sclerosis and Neuromyelitis Optica Center, Southern Tohoku Research Institute for Neuroscience, Koriyama, Japan.3 Research Institute and Hospital of National Cancer Center, Seoul, South Korea.Electronic address: 2 School of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA. Online condolences may be placed at 1 UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. Funeral arrangements are entrusted to the care of the Philbin-Comeau Funeral Home, 176 Water St., Clinton. Box 102, Boylston, MA 01505, or The Church of the Good Shepherd, 209 Union St., Clinton, MA 01510. In lieu of flowers, donations may be made in Barbara’s name to either The Boylston Public Library Foundation, P.O.
Bennett.Ī celebration of life service will be held at 10AM on Thursday, Jat the Church of the Good Shepherd, 209 Union St., Clinton, with a reception to immediate follow in the church fellowship hall.
She is preceded in death by her maternal grandfather Thomas Johnstone, her maternal grandmother Annie Laurie Johnstone, her mother, Helen Bennett, and brothers Lawrence T. Bennett sisters-in-law, Robin Bennett of Berlin, and Debra Bennett of Tampa, FL. Mecum and wife Megan Mecum of Boylston as well as numerous grandchildren and great grandchildren. Fournier and husband William Fournier of Spencer her sons, Barton K. Gouzias and husband James Gouzias of Mashpee Kristen J.
She was active in the community volunteering at food pantries, visiting nursing homes, volunteering to teach English as a second language and crocheting prayer shawls.īarbara is survived by her husband of 53 years, Barton K. She taught in multiple local school districts and was a longtime member of the Church of the Good Shepherd in Clinton. She earned a bachelor’s degree from Framingham State College and a Master’s Degree in Education from Worcester State College. She was a devoted wife who with her husband created an incredible life for her six children, and multiple grandchildren and great grandchildren. Barbara was a remarkable woman who lived life with grace and dignity.
0 kommentar(er)
